Douglas L Mann Selected Research

TNF Receptor-Associated Factor 2 (TRAF2)

3/2022	TRAF2, an Innate Immune Sensor, Reciprocally Regulates Mitophagy and Inflammation to Maintain Cardiac Myocyte Homeostasis.
4/2016	Functional significance of the discordance between transcriptional profile and left ventricular structure/function during reverse remodeling.
1/2015	Tumor necrosis factor receptor-associated factor 2 mediates mitochondrial autophagy.
2/2014	Dysferlin mediates the cytoprotective effects of TRAF2 following myocardial ischemia reperfusion injury.
1/2010	The cytoprotective effects of tumor necrosis factor are conveyed through tumor necrosis factor receptor-associated factor 2 in the heart.

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Douglas L Mann Research Topics

Disease

127	Heart Failure 04/2024 - 01/2002
17	Inflammation (Inflammations) 04/2024 - 11/2002
12	Cardiomyopathies (Cardiomyopathy) 07/2023 - 05/2002
11	Left Ventricular Dysfunction 03/2024 - 11/2002
11	Myocardial Infarction 03/2024 - 11/2003
10	Ischemia 01/2020 - 04/2002
9	Fibrosis (Cirrhosis) 04/2024 - 01/2008
7	Stroke (Strokes) 01/2023 - 01/2013
7	Ventricular Remodeling 01/2020 - 12/2002
5	Reperfusion Injury 01/2020 - 01/2007
5	Systolic Heart Failure 01/2020 - 03/2012
5	Myocardial Ischemia (Ischemic Heart Diseases) 01/2019 - 12/2003
5	Hypertrophy 01/2018 - 01/2004
5	Ischemic Stroke 10/2016 - 05/2012
5	Disease Progression 12/2012 - 12/2002
4	Hypotension (Low Blood Pressure) 11/2023 - 08/2003
4	Coronary Disease (Coronary Heart Disease) 01/2016 - 08/2003
4	Cardiovascular Diseases (Cardiovascular Disease) 01/2016 - 09/2008
4	Hemorrhage 09/2015 - 05/2012
3	Cardiomegaly (Heart Hypertrophy) 12/2023 - 08/2004
3	Myocarditis (Carditis) 12/2023 - 05/2003
3	Takotsubo Cardiomyopathy 02/2023 - 11/2022
3	Atrial Fibrillation 01/2023 - 10/2005
3	Hypertension (High Blood Pressure) 01/2023 - 02/2010
3	Infarction (Infarctions) 01/2019 - 01/2003
3	Cerebral Hemorrhage 01/2016 - 01/2013
3	Hypoxia (Hypoxemia) 01/2015 - 09/2003
3	Coronary Artery Disease (Coronary Atherosclerosis) 05/2013 - 01/2008
3	Infections 10/2010 - 02/2005
3	Body Weight (Weight, Body) 01/2008 - 05/2002
2	ST Elevation Myocardial Infarction 03/2024 - 01/2023
2	Mitral Valve Insufficiency (Mitral Regurgitation) 01/2022 - 02/2003
2	COVID-19 01/2021 - 12/2020
2	Sepsis (Septicemia) 01/2017 - 03/2008
2	Cardiac Sudden Death (Sudden Cardiac Arrest) 04/2016 - 01/2009
2	Cardiogenic Shock 11/2015 - 06/2013

Drug/Important Bio-Agent (IBA)

20	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2017 - 02/2002
14	Proteins (Proteins, Gene)FDA Link 04/2024 - 12/2003
14	CytokinesIBA 01/2020 - 11/2002
13	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 04/2019 - 05/2012
13	Warfarin (Coumadin)FDA LinkGeneric 04/2019 - 05/2012
11	Biomarkers (Surrogate Marker)IBA 11/2017 - 03/2003
10	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 03/2024 - 12/2004
8	CollagenIBA 04/2024 - 01/2003
8	sacubitril and valsartan sodium hydrate drug combinationIBA 03/2024 - 10/2020
5	Mineralocorticoid Receptor AntagonistsIBA 04/2024 - 08/2011
5	Ramipril (Altace)FDA LinkGeneric 03/2024 - 11/2021
5	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2024 - 12/2013
5	Angiotensin Receptors (Angiotensin II Receptor)IBA 11/2023 - 11/2003
5	TNF Receptor-Associated Factor 2 (TRAF2)IBA 03/2022 - 01/2010
5	MicroRNAs (MicroRNA)IBA 07/2013 - 11/2008
5	Etanercept (Enbrel)FDA Link 09/2008 - 04/2004
4	Adrenergic Agents (Adrenergic Drugs)IBA 12/2023 - 03/2003
4	Neprilysin (Neutral Endopeptidase)IBA 11/2023 - 10/2020
4	Angiotensin Receptor AntagonistsIBA 01/2022 - 11/2007
4	Xanthine OxidaseIBA 05/2021 - 06/2008
4	Type 5 Cyclic Nucleotide PhosphodiesterasesIBA 01/2019 - 05/2012
4	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 06/2008 - 01/2006
3	LigandsIBA 04/2024 - 03/2010
3	CreatinineIBA 04/2024 - 10/2004
3	pro-brain natriuretic peptide (1-76)IBA 01/2024 - 01/2022
3	Isoproterenol (Isoprenaline)FDA LinkGeneric 07/2023 - 11/2022
3	Valsartan (Vals)FDA Link 01/2022 - 10/2005
3	CalciumIBA 06/2014 - 09/2003
3	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 01/2014 - 03/2003
3	Matrix Metalloproteinases (MMPs)IBA 05/2013 - 12/2002
3	Fibrillar CollagensIBA 05/2013 - 01/2004
3	Norepinephrine (Noradrenaline)FDA LinkGeneric 08/2004 - 03/2003
2	Metalloproteases (Metalloproteinases)IBA 01/2024 - 08/2008
2	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 03/2022 - 01/2015
2	Plant NectarIBA 01/2022 - 01/2020
2	Spironolactone (Aldactone)FDA LinkGeneric 01/2022 - 01/2017
2	Allopurinol (Remid)FDA LinkGeneric 05/2021 - 05/2015
2	DysferlinIBA 01/2020 - 02/2014
2	C-Reactive ProteinIBA 01/2019 - 08/2008
2	Uric Acid (Urate)IBA 01/2019 - 06/2008
2	AnticoagulantsIBA 01/2018 - 12/2014
2	Messenger RNA (mRNA)IBA 01/2017 - 01/2008
2	HydrogelsIBA 03/2016 - 09/2015
2	AlginatesIBA 03/2016 - 09/2015
2	Hemoglobins (Hemoglobin)IBA 01/2016 - 01/2011
2	DesminIBA 09/2015 - 06/2008
2	HMGB1 Protein (HMG1)IBA 06/2015 - 03/2008
2	Sildenafil Citrate (Viagra)FDA Link 08/2014 - 05/2012
2	DiureticsIBA 12/2013 - 02/2010
2	Toll-Like Receptor 2IBA 03/2010 - 01/2007
2	Creatine Kinase (Creatine Phosphokinase)IBA 01/2010 - 06/2008
2	Transforming Growth Factor beta (TGF-beta)IBA 11/2009 - 01/2008
2	Tumor Necrosis Factor InhibitorsIBA 09/2008 - 04/2004
2	InterleukinsIBA 08/2008 - 05/2005

Therapy/Procedure

49	Therapeutics 04/2023 - 01/2002
17	Heart-Assist Devices 04/2023 - 02/2007
5	Vagus Nerve Stimulation 01/2022 - 06/2012
5	Lung Transplantation 01/2013 - 12/2012
3	Transplantation 01/2021 - 11/2010
2	Percutaneous Coronary Intervention 01/2023 - 09/2013
2	Ligation 12/2022 - 01/2019
2	Implantable Defibrillators (Implantable Cardioverter-Defibrillator) 01/2022 - 04/2019
2	Drug Therapy (Chemotherapy) 01/2022 - 01/2017
2	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 05/2013 - 10/2002